Identification and validation of methylated PENK gene for early detection of bladder cancer using urine DNA

202213 citationsJournal Articlegold Open Access

Authors

Tae Jeong Oh

Eun‐Kyung Lim

Bo‐Ram Bang · Promentis Pharmaceuticals (United States)

Justin Junguek Lee · Promentis Pharmaceuticals (United States)

Yong Gil Na · Chungnam National University

Ju Hyun Shin · Chungnam National University

Jae Sung Lim · Chungnam National University

Ki Hak Song

Abstract

In this study, we analyzed the comprehensive patterns of DNA methylation identified that PENK methylation possesses a high potential as a biomarker for urine-based early detection of BCa. Validation of PENK methylation confirms that it could significantly improve the noninvasive detection of BCa.

Topics & Keywords

Bladder and Urothelial Cancer Treatments Epigenetics and DNA Methylation Urinary and Genital Oncology Studies

Publication Details

Published in: BMC Cancer

Volume 22, Issue 1, pp. 1195-1195

DOI: 10.1186/s12885-022-10275-2

Field-Weighted Citation Impact: 2.40

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Identification and validation of methylated PENK gene for early detection of bladder cancer using urine DNA

Authors

Abstract

Topics & Keywords

Publication Details