Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice

202226 citationsJournal Articlehybrid Open Access

Authors

Edward Milbank · Universidade de Santiago de Compostela

Nathalia Romanelli Vicente Dragano · Instituto de Investigación Sanitaria de Santiago

Xavi Vidal-Gómez · Physiologie et Médecine Expérimentale du Coeur et des Muscles

Verónica Rivas-Limeres · Center for Research in Molecular Medicine and Chronic Diseases

Pablo Garrido‐Gil · Biomedical Research Networking Center on Neurodegenerative Diseases

Mireille Wertheimer · Inserm

Abstract

Overall, this evidence indicates that specific modulation of hypothalamic AMPK using a sEV-based technology may be a suitable strategy against genetic forms of obesity, such as LEPR deficiency.

Topics & Keywords

Regulation of Appetite and Obesity Adipose Tissue and Metabolism Adipokines, Inflammation, and Metabolic Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Metabolism

Volume 139, pp. 155350-155350

DOI: 10.1016/j.metabol.2022.155350

Field-Weighted Citation Impact: 2.14