PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells

2022131 citationsJournal Article

Authors

Yun Li · Sun Yat-sen University

Hengxing Chen · Sun Yat-sen University

Xuan Xie · Sun Yat-sen University

Bing Yang · Sun Yat-sen University

Xiaojuan Wang · Sun Yat-sen University

Jingyuan Zhang · Sun Yat-sen University

Tian Qiao ·

Abstract

DTP cancer cells that cause relapse after anticancer therapy critically depend on PINK1-mediated mitophagy and metabolic reprogramming, providing a therapeutic opportunity to eradicate persister cells to prolong treatment efficacy.

Topics & Keywords

Autophagy in Disease and Therapy Histone Deacetylase Inhibitors Research Adenosine and Purinergic Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Research

Volume 83, Issue 3, pp. 398-413

DOI: 10.1158/0008-5472.can-22-2370

Field-Weighted Citation Impact: 18.39