TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice

2022125 citationsJournal Articlegold Open Access

Authors

Yan Jin · First Affiliated Hospital of Chongqing Medical University

Yuan Zhang · North Sichuan Medical University

Lin Wang · North Sichuan Medical University

Li Zhao · Integrated Chinese Medicine (China)

Shuang Tang · First Affiliated Hospital of Chongqing Medical University

Yingwen Wang · Chongqing Medical University

Nina Gu

Abstract

Altogether, we are the first to demonstrate that TREM2 activation by COG1410 alleviated neural damage through activation of Akt/CREB/BDNF signalling axis in microglia after CCI. Finally, COG1410 treatment improved neurological behaviour and brain electrophysiological activity after CCI.

Topics & Keywords

Inflammation biomarkers and pathways Neuroinflammation and Neurodegeneration Mechanisms Immune Response and Inflammation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 19, Issue 1, pp. 289-289

DOI: 10.1186/s12974-022-02651-3

Field-Weighted Citation Impact: 10.04