Evaluation of the Available Animal Models for Bartonellosis

The diseases caused by the Bartonella genus of bacteria are clinically diverse, difficult to reliably diagnose, and can be challenging to cure. The study of Bartonelloses has been hampered by the lack of a suitable animal model. Preclinical studies for novel therapeutics and a competent host for vector transmission studies are needed to fill critical knowledge gaps. The studies included here are a representation of in vivo Bartonella research and the challenges this line of research faces. This review examines the current state of available animal models by assessing the success of various model species and strains in Bartonella infection. With a focus on the strengths and weaknesses of current animal models, the importance of these models for improvement of human health and veterinary care is emphasized.