Mesenchymal stromal cells ameliorate diabetes‐induced muscle atrophy through exosomes by enhancing AMPK/ULK1‐mediated autophagy

2023107 citationsJournal Articlegold Open Access

Authors

Jia Song · Qilu Hospital of Shandong University

Jidong Liu · Qilu Hospital of Shandong University

Chen Cui · Qilu Hospital of Shandong University

Huiqing Hu · Qilu Hospital of Shandong University

Nan Zang · Qilu Hospital of Shandong University

Mengmeng Yang · Qilu Hospital of Shandong University

H. J. Yang

Abstract

Our results suggest that human umbilical cord mesenchymal stromal cells mitigate diabetes- and obesity-induced muscle atrophy via enhancing AMPK/ULK1-mediated autophagy through exosomes, with implications of applying hucMSCs or hucMSC-derived exosomes to treat muscle atrophy.

Topics & Keywords

Muscle Physiology and Disorders Autophagy in Disease and Therapy Mesenchymal stem cell research

UN Sustainable Development Goals

Responsible consumption and production

Publication Details

Published in: Journal of Cachexia Sarcopenia and Muscle

Volume 14, Issue 2, pp. 915-929

DOI: 10.1002/jcsm.13177

Field-Weighted Citation Impact: 16.41