In vivo photopharmacology with light-activated opioid drugs

20232 citationsPreprintgreen Open Access

Authors

Shannan P. McClain · University of California San Diego

Xiang Ma · University of California San Diego

Desiree A. Johnson · University of California San Diego

Caroline A. Johnson · University of California San Diego

Aryanna E. Layden · University of California San Diego

Jean C. Yung · University of California San Diego

Susan T. Lubejko

Abstract

A photoactivatable opioid agonist (PhOX) and antagonist (PhNX) for in vivo photopharmacology. Systemic pro-drug delivery followed by local photoactivation in the brain. In vivo photopharmacology produces behavioral changes within seconds of photostimulation. In vivo photopharmacology enables all-optical pharmacology and physiology.

Topics & Keywords

Photochromic and Fluorescence Chemistry Photoreceptor and optogenetics research Memory and Neural Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2023.02.02.526901

Command Palette

<i>In vivo</i> photopharmacology with light-activated opioid drugs

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details