Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha

202337 citationsJournal Articlehybrid Open Access

Authors

Avinash Sahu · Dana-Farber Cancer Institute

Xiaoman Wang · Chinese Academy of Medical Sciences & Peking Union Medical College

Phillip Munson · Massachusetts General Hospital

Jan P.G. Klomp · Pharmaleads (France)

Xiaoqing Wang · Chinese Academy of Medical Sciences & Peking Union Medical College

Shengqing Gu · Dana-Farber Cancer Institute

Ya Han

Abstract

BipotentR presents resources for evaluating patient response and identifying targets for drugs that can kill tumors through multiple mechanisms concurrently. Inhibition of the topmost candidate target killed tumors by suppressing energy metabolism and effects on two immune mechanisms. This article is highlighted in the In This Issue feature, p. 517.

Topics & Keywords

Computational Drug Discovery Methods Cancer Immunotherapy and Biomarkers Immune cells in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Discovery

Volume 13, Issue 3, pp. 672-701

DOI: 10.1158/2159-8290.cd-22-0244

Field-Weighted Citation Impact: 7.13

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