A Retrospective Review of 307 Men With Peyronie’s Disease

No AccessJournal of UrologyCLINICAL UROLOGY: ORIGINAL ARTICLES1 Sep 2002A Retrospective Review of 307 Men With Peyronie's Disease Ateş Kadioglu, Ahmet Tefekli, Bulent Erol, Tayfun Oktar, Murat Tunc, and Sedat Tellaloglu Ateş KadiogluAteş Kadioglu , Ahmet TefekliAhmet Tefekli , Bulent ErolBulent Erol , Tayfun OktarTayfun Oktar , Murat TuncMurat Tunc , and Sedat TellalogluSedat Tellaloglu View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64578-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We discuss the clinical appearance and natural outcome of Peyronie's disease. Materials and Methods: During an 8-year period 307 men with Peyronie's disease were evaluated, and clinical characteristics, risk (factors), penile deformities, erectile status and outcome were analyzed. Results: Mean patient age plus or minus standard deviation was 52.8 ± 9.3 years (range 23 to 76). Penile deformity, pain on erection and palpable nodule were the most common (85%) presenting symptoms, usually in different combinations. The remaining 15% of men (mean age 59.4 ± 6.5 years) were not aware of the penile deformity and were diagnosed during standard evaluation for erectile dysfunction. Dorsal (45.6%) and lateral (29.3%) were the most common curvatures. The degree of deformity was less than 30 degrees in 42.7% of patients, 31 to 60 degrees in 38.8% and greater than 60 degrees in 18.6%. At least 1 risk factor for systemic vascular disease was identified in 67.5% of patients, and hypercholesterolemia and diabetes were the most common. Patients with at least 1 risk factor had a significantly higher risk for severe penile deformity. Of the men 54.4% complained of erectile dysfunction and the probability of diminished erectile capacity was 86.7% in patients older than 60 years, with Peyronie's disease for more than 12 months and at least 1 risk factor. Of 63 patients presenting with the acute phase of disease penile deformity deteriorated in 30.2%, did not change in 66.7% and resolved spontaneously in 3.2% without any treatment after a mean followup of 8.4 months. Conclusions: Our data show that penile deformities are disabling (greater than 30 degrees) in 62.5% of cases. Risk factors, such as serum lipid abnormalities, diabetes and hypertension, seem to have significant impact on the severity of symptoms and outcome. Patients must be informed that Peyronie's disease is progressive in 30.2% without treatment and spontaneous resolution is rare. References 1 : Peyronie's disease. Am J Clin Path1966; 45: 670. Google Scholar 2 : The anatomy of the tunica albuginea in the normal penis Peyronie's disease. J Urol1997; 157: 276. Link, Google Scholar 3 : Peyronie's disease: etiology, medical, surgical therapy. J Androl2000; 21: 347. Google Scholar 4 : Prevalence of Peyronie's disease—results of a 8,000 men survey. Eur Urol2000; 37: 58. 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Abstract, Google Scholar From the Department of Urology, Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byStewart C, Yafi F, Knoedler M, Mandava S, McCaslin I, Sangkum P, Sikka S, Trost L and Hellstrom W (2018) Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men with Peyronie's Disease Independent of Plaque LocationJournal of Urology, VOL. 194, NO. 6, (1704-1707), Online publication date: 1-Dec-2015.Gelbard M, Lipshultz L, Tursi J, Smith T, Kaufman G and Levine L (2018) Phase 2b Study of the Clinical Efficacy and Safety of Collagenase Clostridium Histolyticum in Patients With Peyronie DiseaseJournal of Urology, VOL. 187, NO. 6, (2268-2274), Online publication date: 1-Jun-2012.Greenfield J, Shah S and Levine L (2018) Verapamil Versus Saline in Electromotive Drug Administration for Peyronie's Disease: A Double-Blind, Placebo Controlled TrialJournal of Urology, VOL. 177, NO. 3, (972-975), Online publication date: 1-Mar-2007.Mulhall J, Schiff J and Guhring P (2018) An Analysis of the Natural History of Peyronie's DiseaseJournal of Urology, VOL. 175, NO. 6, (2115-2118), Online publication date: 1-Jun-2006.KENDIRCI M, NOWFAR S, GUR S, JABREN G, SIKKA S and HELLSTROM W (2018) THE RELATIONSHIP BETWEEN THE TYPE OF PENILE ABNORMALITY AND PENILE VASCULAR STATUS IN PATIENTS WITH PEYRONIE'S DISEASEJournal of Urology, VOL. 174, NO. 2, (632-635), Online publication date: 1-Aug-2005.USTA M, BIVALACQUA T, JABREN G, MYERS L, SANABRIA J, SIKKA S and HELLSTROM W (2018) Relationship Between the Severity of Penile Curvature and the Presence of Comorbidities in Men With Peyronie's DiseaseJournal of Urology, VOL. 171, NO. 2, (775-779), Online publication date: 1-Feb-2004.HAUCK E, MUELLER U, BSCHLEIPFER T, SCHMELZ H, DIEMER T and WEIDNER W (2018) Extracorporeal Shock Wave Therapy for Peyronie's Disease: Exploratory Meta-Analysis of Clinical TrialsJournal of Urology, VOL. 171, NO. 2, (740-745), Online publication date: 1-Feb-2004.USTA M, BIVALACQUA T, TOKATLI Z, RIVERA F, GULKESEN K, SIKKA S and HELLSTROM W (2018) STRATIFICATION OF PENILE VASCULAR PATHOLOGIES IN PATIENTS WITH PEYRONIE'S DISEASE AND IN MEN WITH ERECTILE DYSFUNCTION ACCORDING TO AGE: A COMPARATIVE STUDYJournal of Urology, VOL. 172, NO. 1, (259-262), Online publication date: 1-Jul-2004.HAUCK E, DOMANN E, HAUPTMANN A, WEIDNER W, CHAKRABORTY T and HOSSAIN H (2018) Prospective Analysis of 16S rDNA as a Highly Sensitive Marker for Bacterial Presence in Peyronie's Disease PlaquesJournal of Urology, VOL. 170, NO. 5, (2053-2056), Online publication date: 1-Nov-2003. Volume 168Issue 3September 2002Page: 1075-1079 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordspenile erectionPenile Indurationrisk factorsnatural historyMetricsAuthor Information Ateş Kadioglu More articles by this author Ahmet Tefekli More articles by this author Bulent Erol More articles by this author Tayfun Oktar More articles by this author Murat Tunc More articles by this author Sedat Tellaloglu More articles by this author Expand All Advertisement PDF downloadLoading ...