CAN THYROID PROFILE PREDICT THE IMPENDING DANGER OF DECOMPENSATION IN LIVER CIRRHOSIS?

Background: Chronic liver disease is one of the world's leading causes of mortality and morbidity. Thyroid and liver are interdependent in their functioning, Thyroid gland regulates basic metabolic rate in hepatocytes and liver being the site of thyroid hormone metabolism, modulates hormone levels. Assessment of thyroid levels in cirrhosis may prove useful to identify severity of disease and probability of complication rates. In this context we conducted a study to signify the association between thyroid hormones and severity of hepatic disorder in cirrhosis through usage of Child Pugh score. 100 patients a Method: ged 18 years and above, with liver cirrhosis were evaluated in our institute. Thyroid prole and other relevant investigations were carried out to assess severity of liver cirrhosis, correlated with Child Pugh scoring. Results: 74% of the patients in the study were in euthyroid state. Total and free T3, T4 levels were signicantly low and inversely correlated with severity of liver cirrhosis. Most of the patients had normal T4 and TSH levels. Among all, free T3 was found to be the most sensitive marker to assess severity of cirrhosis. Thyroid dysfunction is oft Conclusion: en observed in liver cirrhosis which calls for thyroid prole tests to be conducted with a potential role as prognostic marker.