Polypyrimidine Tract Binding Protein 1 Exacerbates Cardiac Fibrosis by Regulating Fatty Acid-Binding Protein 5

PTBP1 contributed to cardiac fibrosis via promoting CF proliferation and collagen deposition through Nur77 mRNA decay and subsequent transcription inhibition of FABP5. Our findings suggest that PTBP1/Nur77/FABP5 axis may be potential targets for cardiac fibrosis therapy.