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For our knowledge, this appears to be first Iraqi study aimed for detection the concentration of pancreatic exocrine enzymes and endocrine hormones as well as lipid profile in obese, diabetic as well as obese/diabetic mice. Totally, 80 adult male mice, Mus musculus were selected, prepared, divided to 4 groups, and submitted to experimentally period continued for 2 months, July and August 2021. The findings of pancreatic enzymes showed a significant decrease in values of amylase in diabetic and obese/diabetic mice. In the case of lipase, insignificant differences were observed between obese/diabetics, but not in obese/diabetic group. No significant differences were found between the concentrations of chymotrypsin throughout all study groups. Trypsin reduction was observed in diabetic and obese/diabetic groups. The findings of pancreatic hormones detected higher concentration of gastrin in diabetic mice, and lowered in obese/diabetic ones. Glucagon elevation was found in diabetic and obese/diabetic groups, while reduction in diabetic group. Though obese mice were revealed a high insulin concentration, diabetic and obese/diabetic groups showed lowering. There was significant reduction in levels of somatostatin in mice of diabetic and obese/diabetic groups. Significant decreases in values of vasoactive intestinal polypeptide were observed in mice of diabetic and obese/diabetic groups. In the case of lipid profile, there were significant increases in values of triglyceride among the groups of diabetic and obese/diabetic groups. Significant HDL reduction were recorded in diabetic and obese/diabetic groups, while higher values in obese group. In the case of LDL, total cholesterol and total cholesterol / HDL ratio exhibited significant increases among mice of obese/diabetic group, while decreases in obese/diabetics. In conclusion, pancreatic exocrine enzymes were positively impaired in diabetic as well as obese/diabetic groups but not in obese group; whereas, pancreatic endocrine hormones and lipid profiles were affected among all diseased groups when compared to control group. The role of pancreatic enzymes as well as hormones in the pathogenesis of metallic disorders warrants further investigations.