Randomized Trial of Targeted Transendocardial Mesenchymal Precursor Cell Therapy in Patients With Heart Failure

202387 citationsJournal Articlehybrid Open Access

Authors

Emerson C. Perin · Houston Institute for Clinical Research

Kenneth M. Borow · Bryn Mawr College

Timothy D. Henry · Christ Hospital

Farrell O. Mendelsohn · Princeton Baptist Medical Center

Leslie W. Miller · Morton Plant Hospital

Elizabeth Swiggum · University of British Columbia

Eric Adler

Abstract

The primary and secondary endpoints of the trial were negative. Positive signals in prespecified, and post hoc exploratory analyses suggest MPCs may improve outcomes, especially in patients with inflammation.

Topics & Keywords

Cardiovascular Function and Risk Factors Mechanical Circulatory Support Devices Cardiac Structural Anomalies and Repair

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of the American College of Cardiology

Volume 81, Issue 9, pp. 849-863

DOI: 10.1016/j.jacc.2022.11.061

Field-Weighted Citation Impact: 19.00