The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition

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Authors

Ayalur Raghu Subbalakshmi · Indian Institute of Science Bangalore

Sarthak Sahoo · Indian Institute of Science Bangalore

Prakruthi Manjunatha · M.S. Ramaiah Medical College

Shaurya Goyal · Indian Institute of Technology Kharagpur

Vignesh A Kasiviswanathan · JSS Science and Technology University

Yeshwanth Mahesh · Indian Institute of Science Bangalore

Soundharya Ramu

Abstract

ELF3 is shown to be inhibited during EMT progression and is also found to inhibit the progression of complete EMT suggesting that ELF3 may be able to counteract EMT induction, including in the presence of EMT-inducing factors, such as WT1. The analysis of patient survival data indicates that the prognostic capacity of ELF3 is specific to cell-of-origin or lineage.

Topics & Keywords

Cancer Cells and Metastasis Cancer Genomics and Diagnostics Cancer-related molecular mechanisms research

Publication Details

Published in: Journal of Biological Engineering

Volume 17, Issue 1, pp. 17-17

DOI: 10.1186/s13036-023-00333-z

Field-Weighted Citation Impact: 7.90

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The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition

Authors

Abstract

Topics & Keywords

Publication Details