TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury

202361 citationsJournal Articlegold Open Access

Authors

Wenjing Zhong · Central South University

Jun Zhang · Hunan University

Jia‐Xi Duan · Central South University

Chen‐Yu Zhang · Central South University

Shengchao Ma · Ningxia Medical University

Yusheng Li · Central South University

Nan‐Shi‐Yu Yang ·

Abstract

In this study, we reported that TREM-1 acted as a necroptotic stimulus of AlvMs, fueling inflammation and aggravating ALI. We also provided compelling evidence suggesting that mTOR-dependent mitochondrial fission is the underpinning of TREM-1-triggered necroptosis and inflammation. Therefore, regulation of necroptosis by targeting TREM-1 may provide a new therapeutic target for ALI in the future.

Topics & Keywords

Inflammation biomarkers and pathways Intensive Care Unit Cognitive Disorders Inflammasome and immune disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Translational Medicine

Volume 21, Issue 1, pp. 179-179

DOI: 10.1186/s12967-023-04027-4

Field-Weighted Citation Impact: 10.04