Supplementary Information from Antibody-Mediated Endocytosis of Polysialic Acid Enables Intracellular Delivery and Cytotoxicity of a Glycan-Directed Antibody–Drug Conjugate

<p>This is a single pdf file that contains: (1) supplementary methods; (2) supplementary table 1 (microarray glycans), supplementary table 2 (ADCs), and supplementary table 3 (primers); (3) supplementary figure 1 (ch735 Ab expression/purification), supplementary figure 2 (mo735 mAb ELISA), supplementary figure 3 (mo735 glycan microarray profiling), supplementary figure 4 (binding affinity data), supplementary figure 5 (histograms of Ab-stained cell lines), supplementary figure 6 (cell surface binding of cancer cell lines), supplementary figure 7 (CRISPR-Cas knockout cell lines), supplementary figure 8 (internalization of mo735), supplementary figure 9 (colocalization of mo735), and supplementary figure 10 (synthesis of ADC).</p>