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Relevance . The isolation of prosthetic periodontitis among inflammatory periodontal pathology has significantly supplemented the generally accepted notions of dentists concerning the etiology and progression of dental prosthetics complications. Improving the methods of preventing inflammatory periodontal lesions caused by the presence of denture structures in the oral cavity is very relevant nowadays, especially in persons using removable dental prostheses. This applies to older age groups, which for financial reasons are more accessible removable acrylic dentures, which they have the opportunity to get at the expense of the budget of the region. Aim . This applies to those in the older age groups who, for financial reasons, have more access to removable acrylic dentures because of the possibility of obtaining dentures at the expense of the regional budget. Therefore, the aim of the study was to assess the possibility of using a new domestic denture fixation cream for the prevention of prosthetic periodontitis in patients using removable dentures. Materials and methods . 63 (18 male and 45 female) elderly patients (61-74 years old) with partial tooth loss on both jaws were examined. Partial removable acrylic dentures were made for patients 1st group (n = 30) and 2nd group (n = 33). The patients of the second group constantly used the domestic ASEPTA РARODONTAL denture fixation cream with herbal extract for 9 months of the study. Assessment of the impact of dentures on the oral tissues and periodontium was carried out on the basis of clinical examination and by studying the antimicrobial potential of saliva. Results . The use of partial removable acrylic dentures has been found to contribute to the occurrence of prosthetic periodontitis, which is associated with the technology used in their manufacture. It is possible to reduce the incidence of prosthetic periodontitis not only by timely correction of prosthesis but also by using adhesive means for fixation of prosthesis, the application of which permitted to reduce the occurrence of prosthetic periodontitis by 47,58% and to reduce the occurrence of inflammatory changes of gingiva in the restored teeth area by 16,06%. The research of the antimicrobial potential of saliva in persons who constantly used ASEPTA РARODONTAL denture fixation cream with herbal extract showed that the immune balance achieved before dental prosthetics can be maintained in the oral cavity. Conclusion . The results of the clinical and laboratory study allow us to recommend more widely the use of adhesive means for fixation of removable dentures, including the ASEPTA PARODONTAL cream with herbal extracts.