Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

202377 citationsJournal Articlegold Open Access

Authors

Daniela Matuozzo · Inserm

Estelle Talouarn · Inserm

Astrid Marchal · Inserm

Peng Zhang · Rockefeller University

Jérémy Manry · Inserm

Yoann Seeleuthner · Inserm

Yu Zhang · National Institute of Allergy and Infectious Diseases

Abstract

Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

Topics & Keywords

interferon and immune responses SARS-CoV-2 and COVID-19 Research Immune responses and vaccinations

Publication Details

Published in: Genome Medicine

Volume 15, Issue 1, pp. 22-22

DOI: 10.1186/s13073-023-01173-8

Field-Weighted Citation Impact: 12.59

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Authors

Abstract

Topics & Keywords

Publication Details