MELAS: Phenotype Classification into Classic-versus-Atypical Presentations

202328 citationsReviewhybrid Open Access

Authors

Cesar Alves · Anna Needs Neuroblastoma Answers

Alireza Zandifar · Anna Needs Neuroblastoma Answers

James T. Peterson · MRC Mitochondrial Biology Unit

Seyedeh Zahra Tara · MRC Mitochondrial Biology Unit

Rebecca Ganetzky · Dr. M.G.R. Educational and Research Institute

Angela N. Viaene · Children's Hospital of Philadelphia

Savvas Andronikou

Abstract

We identified 2 distinct patterns of MELAS: classic MELAS and atypical MELAS. Recognizing different patterns in MELAS presentations will enable clinical and research care teams to better understand the natural history and prognosis of MELAS and identify the best candidates for specific therapeutic interventions.

Topics & Keywords

Mitochondrial Function and Pathology RNA modifications and cancer interferon and immune responses

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Neuroradiology

Volume 44, Issue 5, pp. 602-610

DOI: 10.3174/ajnr.a7837

Field-Weighted Citation Impact: 4.29