TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer

202316 citationsJournal Articlebronze Open Access

Authors

Aditi S. Khatpe · Indiana University – Purdue University Indianapolis

Rebecca Dirks · Indiana University – Purdue University Indianapolis

Poornima Bhat‐Nakshatri · Indiana University – Purdue University Indianapolis

Henry Mang · Indiana University – Purdue University Indianapolis

Katie Batic · Indiana University – Purdue University Indianapolis

Sarah Swiezy · Indiana University – Purdue University Indianapolis

Abstract

The chr.8q24.3 amplicon-resident gene TONSL is upregulated during the initial steps of tumorigenesis to support neoplastic transformation by increasing DNA repair and represents a potential therapeutic target for treating breast cancer.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Research

Volume 83, Issue 8, pp. 1345-1360

DOI: 10.1158/0008-5472.can-22-3667

Field-Weighted Citation Impact: 3.68