KIAA1429-mediated m6A modification of CHST11 promotes progression of diffuse large B-cell lymphoma by regulating Hippo–YAP pathway

202339 citationsJournal Articlegold Open Access

Authors

Xiaohong Chen · Shandong Provincial Hospital

Tiange Lu · Shandong Provincial Hospital

Yiqing Cai · Shandong Provincial Hospital

Yang Han · Shandong Provincial Hospital

Mengfei Ding · Shandong Provincial Hospital

Yurou Chu · Shandong Provincial Hospital

Xiangxiang Zhou ·

Abstract

Our results revealed a new mechanism by which the Hippo-YAP pathway in DLBCL is inactivated by KIAA1429/YTHDF2-coupled epitranscriptional repression of CHST11, highlighting the potential of KIAA1429 as a novel predictive biomarker and therapeutic target for DLBCL progression.

Topics & Keywords

RNA modifications and cancer Cancer-related gene regulation Ubiquitin and proteasome pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cellular & Molecular Biology Letters

Volume 28, Issue 1, pp. 32-32

DOI: 10.1186/s11658-023-00445-w

Field-Weighted Citation Impact: 6.38