P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis

20239 citationsJournal Articlegold Open Access

Authors

Peijie Zhong · Henan University Huaihe Hospital and Huaihe Clinical Institute

Hang Wu · Henan University Huaihe Hospital and Huaihe Clinical Institute

Yuanqiao Ma · Henan University Huaihe Hospital and Huaihe Clinical Institute

Xiaoxiao Xu · Henan University Huaihe Hospital and Huaihe Clinical Institute

Yizhuo Jiang · Henan University Huaihe Hospital and Huaihe Clinical Institute

Chaolei Jin · Henan University Huaihe Hospital and Huaihe Clinical Institute

Abstract

Our findings elaborate on an unrevealed etiopathophysiological mechanism by which microbiota dysbiosis induced by the P2X4 receptor influences the development of colitis, indicating that the P2X4 receptor represents a promising target for treating patients with CD and UC.

Topics & Keywords

Gastroesophageal reflux and treatments Gut microbiota and health Eosinophilic Esophagitis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical and Translational Medicine

Volume 13, Issue 4, pp. e1227-e1227

DOI: 10.1002/ctm2.1227

Field-Weighted Citation Impact: 2.53