YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

2023247 citationsJournal Articlegold Open Access

Authors

Xiaotang Wang · National Clinical Research Center for Digestive Diseases

Wei Fan · National Clinical Research Center for Digestive Diseases

Na Li · Chongqing Medical University

Yan Ma · Nanjing Medical University

Mudi Yao · Nanjing Medical University

Guoqing Wang · National Clinical Research Center for Digestive Diseases

Siyuan He

Abstract

Our results suggest that YY1 lactylation in microglia plays an important role in retinal neovascularization by upregulating FGF2 expression. Targeting the lactate/p300/YY1 lactylation/FGF2 axis may provide new therapeutic targets for proliferative retinopathies.

Topics & Keywords

Retinal Diseases and Treatments Zebrafish Biomedical Research Applications Neuroinflammation and Neurodegeneration Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 24, Issue 1, pp. 87-87

DOI: 10.1186/s13059-023-02931-y

Field-Weighted Citation Impact: 67.79