Neutrophil extracellular traps induced by the hypoxic microenvironment in gastric cancer augment tumour growth

202384 citationsJournal Articlegold Open Access

Authors

Jiacheng Li · First Affiliated Hospital of Jiamusi University

Yu Xia · First Affiliated Hospital of Jiamusi University

Biying Sun · First Affiliated Hospital of Jiamusi University

Nanbei Zheng · First Affiliated Hospital of Jiamusi University

Yang Li · First Affiliated Hospital of Jiamusi University

Xuehan Pang · First Affiliated Hospital of Jiamusi University

Fan Yang

Abstract

Hypoxia triggers an inflammatory response and NET formation in the GC TIME to augment tumour growth. Targeting NETs with DNase I or HMGB1/TLR4/p38 MAPK pathway inhibitors is a potential therapeutic strategy to inhibit GC progression. Video Abstract.

Topics & Keywords

Immune cells in cancer Neutrophil, Myeloperoxidase and Oxidative Mechanisms Chemokine receptors and signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cell Communication and Signaling

Volume 21, Issue 1, pp. 86-86

DOI: 10.1186/s12964-023-01112-5

Field-Weighted Citation Impact: 14.61