Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin

202328 citationsJournal Articlebronze Open Access

Authors

Tatsuro Hitsumoto · The University of Osaka

Osamu Tsukamoto · Hyogo Medical University

Ken Matsuoka · The University of Osaka

Junjun Li · The University of Osaka

Li Liu · The University of Osaka

Yuki Kuramoto · The University of Osaka

Shuichiro Higo ·

Abstract

cMLCK dysregulation contributes to the development of cardiac systolic dysfunction in humans. Our strategy to restore cMLCK activity could form the basis of a novel myotropic therapy for advanced systolic heart failure.

Topics & Keywords

Cardiomyopathy and Myosin Studies Signaling Pathways in Disease Cardiac Fibrosis and Remodeling

Publication Details

Published in: Circulation

Volume 147, Issue 25, pp. 1902-1918

DOI: 10.1161/circulationaha.122.062885

Field-Weighted Citation Impact: 6.15

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Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin

Authors

Abstract

Topics & Keywords

Publication Details