Efficacy of dual <scp>enkephalinase</scp> inhibition in a preclinical migraine model is mediated by activation of peripheral delta opioid receptors

These data demonstrate that inhibiting enkephalinases, and thus protecting enkephalins from degradation, attenuates stress-induced migraine-like behavior via activation of peripheral DOR. Peripheral targeting of endogenous opioid signaling may be an effective therapeutic strategy for migraine.