Clinical Characteristics of Heart Failure with Reduced Ejection Fraction Patients with Rare Pathogenic Variants in Dilated Cardiomyopathy-Associated Genes: A Subgroup Analysis of the PARADIGM-HF Trial

Deleterious pLoF variants in genes with definitive/strong association with DCM were identified in ∼5% of HFrEF patients from a PARADIGM-HF trial subset, who were younger, had lower ejection fraction and were less likely to have had an ischaemic aetiology.