Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression

202351 citationsJournal Articlediamond Open Access

Authors

Qian Guan · South China University of Technology

Huiran Lin · Macau University of Science and Technology

Wenfeng Hua

Lei Lin · South China University of Technology

Jiabin Liu · South China University of Technology

Linqing Deng · South China University of Technology

Jiao Zhang · First Affiliated Hospital of Zhengzhou University

Abstract

We first found that the rs8400 G>A polymorphism in the m6A demethylase-encoding gene ALKBH5 increases neuroblastoma susceptibility and determines the related mechanisms. The aberrant regulation of ALKBH5 by miR-186-3p caused by this genetic variation in ALKBH5 promotes the occurrence and development of neuroblastoma through the ALKBH5-SPP1 axis.

Topics & Keywords

Neuroblastoma Research and Treatments RNA modifications and cancer Cancer, Hypoxia, and Metabolism

Publication Details

Published in: Chinese Journal of Cancer Research

Volume 35, Issue 2, pp. 140-162

DOI: 10.21147/j.issn.1000-9604.2023.02.05

Field-Weighted Citation Impact: 10.75

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Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression

Authors

Abstract

Topics & Keywords

Publication Details