Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system

202324 citationsJournal Articlegold Open Access

Authors

Vera Fominykh · University of Oslo

Alexey Shadrin · University of Oslo

Piotr Jahołkowski · University of Oslo

Shahram Bahrami · University of Oslo

Lavinia Athanasiu · Oslo University Hospital

Douglas P. Wightman · Amsterdam Neuroscience

Emil Uffelmann ·

Abstract

Despite low global genetic correlation, the current results provide evidence for polygenic overlap between AD and MS. The shared loci between AD and MS were enriched in pathways involved in inflammation and neurodegeneration, highlighting new opportunities for future investigation.

Topics & Keywords

Bioinformatics and Genomic Networks Alzheimer's disease research and treatments Genetic Associations and Epidemiology

Publication Details

Published in: Neurobiology of Disease

Volume 183, pp. 106174-106174

DOI: 10.1016/j.nbd.2023.106174

Field-Weighted Citation Impact: 3.68

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Shared genetic loci between Alzheimer's disease and multiple sclerosis: Crossroads between neurodegeneration and immune system

Authors

Abstract

Topics & Keywords

Publication Details