Homocysteine promotes atherosclerosis through macrophage pyroptosis via endoplasmic reticulum stress and calcium disorder

202362 citationsJournal Articlegold Open Access

Authors

Shan Zhang · Harbin Medical University

Ying Lv · Harbin Medical University

Xing Luo · Harbin Medical University

Xiuzhu Weng · Harbin Medical University

Jinyu Qi · Harbin Medical University

Xiaoxuan Bai · Harbin Medical University

Chen Zhao ·

Abstract

Homocysteine accelerates atherosclerosis progression by enhancing macrophages pyroptosis via promoting endoplasmic reticulum stress, endoplasmic reticulum-mitochondria coupling, and disturbing of calcium disorder.

Topics & Keywords

Inflammasome and immune disorders Gout, Hyperuricemia, Uric Acid Heme Oxygenase-1 and Carbon Monoxide

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Medicine

Volume 29, Issue 1, pp. 73-73

DOI: 10.1186/s10020-023-00656-z

Field-Weighted Citation Impact: 9.53