Fabrication and Characterization of Curcumin-loaded Gelatin Nanoparticle Using A Two-Step Desolvation Protocol

Recently gelatin nanoparticles (G-NPs) have been gaining substantial consideration because they offer excellent properties like low cost, biocompatibility, and biodegradability. One of the protein materials that can be utilized to make nanoparticles is gelatin. The emphasis is constructed on the datum that gelatin is non-toxic, easy to crosslink, and chemically changeable, and hence consumes a gigantic potential for colloidal drug delivery system synthesis. The surface of G-NPs can be easily cat-ionized with a variety of amine derivatives to provide targeted and sustained drug delivery. Curcumin-loaded gelatin G-NPs were manufactured using a two-step desolvation progression in this study. A glutaraldehyde cross-linker was also employed to provide G-NP with good stability. Inclusive, the ordinary size of the curcumin-loaded gelatin (CGNPs) was 112 nm, with a zeta potential of +31.80 mV. An In-vitro dissolution study confirmed 88 % of the drug was released from the CGNP within 24 h. In comparison, drug release showed a lower release rate, at about 66 % after 24 h. In the present work, we fabricated a curcumin-loaded gelatin nanoparticle to improve the solubility and thereby enhance the stability of a formulation, which will further encourage the progress of curcumin based on nanoformulation. Curcumin-loaded gelatin nanoparticles have a higher stability in biological fluids than colloidal carriers, allowing for the desired delimited and unrelenting release of encapsulated drug molecules. In all, the fabricated curcumin-loaded gelatin nanoparticle proved to be a sustained-release drug delivery system.