Putative 14th Century Outbreak of Foodborne Chagas Disease, Mexico

A severe epidemic erupted in Coyoacán at the southern end of Lake Texcoco, in Central Mexico, around 1330. Chroniclers of the 16th century reported that after disrupted fish supply, the inhabitants of Coyoacán had suffered high morbidity and mortality. They developed edema of their eyelids, face, and feet, and hemorrhagic diarrhea. Many died, mainly the young and the old. Pregnant women miscarried. The disease is classically considered an illness of nutritional origin. However, its clinical picture and the circumstances of its emergence are remarkably consistent with an outbreak of foodborne Chagas disease, possibly acquired upon the hunting and consumption of alternative food sources, such as infected opossums (<i>Didelphis</i> spp.), unique reservoirs of <i>Trypanosoma cruzi</i>.