Hyaluronan synthesis inhibition normalizes ethanol‐enhanced hepatic stellate cell activation

20236 citationsJournal Articlebronze Open Access

Authors

Manasi Kotulkar · University of Kansas Medical Center

Dakota R. Robarts · University of Kansas Medical Center

Kristi Lin‐Rahardja · University of Kansas Medical Center

Tara E. McQuillan · University of Kansas Medical Center

Jordan Surgnier · University of Kansas Medical Center

Sarah E. Tague · University of Kansas Medical Center

Maciej Czerwiński

Abstract

These data show that ethanol augments HSC activation through HA synthesis and enhances hepatic profibrogenic features. Therefore, targeting HSC HA production could potentially attenuate liver disease in ALD patients.

Topics & Keywords

Alcohol Consumption and Health Effects Liver Disease Diagnosis and Treatment Proteoglycans and glycosaminoglycans research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alcohol Clinical and Experimental Research

Volume 47, Issue 8, pp. 1544-1559

DOI: 10.1111/acer.15127

Field-Weighted Citation Impact: 1.56