Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study

2023107 citationsJournal Articlehybrid Open Access

Authors

Fátima Sánchez‐Cabo · Spanish National Centre for Cardiovascular Research

Valentı́n Fuster · Cardiovascular Institute of the South

Juan Carlos Silla-Castro · Spanish National Centre for Cardiovascular Research

Gema González · Spanish National Centre for Cardiovascular Research

Erika Lorenzo-Vivas · Spanish National Centre for Cardiovascular Research

Rebeca Álvarez · Spanish National Centre for Cardiovascular Research

Abstract

The presence, extension, and progression of subclinical atherosclerosis in middle-aged asymptomatic individuals are associated with an acceleration in the Grim epigenetic age. Mediation analysis using transcriptomics and proteomics data suggests a key role of systemic inflammation in this association, reinforcing the relevance of interventions on inflammation to prevent cardiovascular disease.

Topics & Keywords

Epigenetics and DNA Methylation Birth, Development, and Health Pregnancy and preeclampsia studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Heart Journal

Volume 44, Issue 29, pp. 2698-2709

DOI: 10.1093/eurheartj/ehad361

Field-Weighted Citation Impact: 16.47