Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses

202314 citationsJournal Articlehybrid Open Access

Authors

Niki Dimou · Centre international de recherche sur le cancer

Andre E. Kim · University of Southern California

Orlagh Flanagan · Centre international de recherche sur le cancer

Neil Murphy · Centre international de recherche sur le cancer

Virginia Díez‐Obrero · Institut d'Investigació Biomédica de Bellvitge

Anna Shcherbina · Stanford University

Elom K. Aglago

Abstract

These results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.

Topics & Keywords

Genetic Associations and Epidemiology Liver Disease Diagnosis and Treatment Bioinformatics and Genomic Networks

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Cancer

Volume 129, Issue 3, pp. 511-520

DOI: 10.1038/s41416-023-02312-z

Field-Weighted Citation Impact: 4.38