STING mediates microglial pyroptosis via interaction with NLRP3 in cerebral ischaemic stroke

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Authors

Wenyu Li · University of Science and Technology of China

Nan Shen · University of Science and Technology of China

Lingqi Kong · University of Science and Technology of China

Hongmei Huang · University of Science and Technology of China

Xinyue Wang · University of Science and Technology of China

Yan Zhang · University of Science and Technology of China

Guoping Wang

Abstract

The current findings indicate that STING modulates NLRP3-mediated microglial pyroptosis following MCAO. STING may serve as a therapeutic target in neuroinflammation induced by cerebral ischaemic/reperfusion (I/R) injury.

Topics & Keywords

Inflammasome and immune disorders interferon and immune responses Immune Response and Inflammation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stroke and Vascular Neurology

Volume 9, Issue 2, pp. 153-164

DOI: 10.1136/svn-2023-002320

Field-Weighted Citation Impact: 13.04