Effects of Onion extract on Ulcerative Colitis in Rats

Background and Aim: The purpose of the present study is to provide a basis for the use of onion as a therapeutic agent for Ulcerative Colitis (UC). Methods: The rat’s model of UC induced by acetic acid administration intrarectally as previously described and the effect of onion extract was evaluated through the measurement of colonic biometrics, colonic Myeloperoxidase (MPO) activity and serum Lactate Dehydrogenase (LDH) activity in this model. Results: In rat treated with onion (300mg/kg, orally) colonic biometrics including weight and length at the 5th day after acetic acid administration was significantly improved. Colonic MPO activity was significantly decreased in onion extract group, while that in UC group significantly increased compared to control. LDH activity in serum was significantly elevated in UC group, but the administration of onion extract improved it. Conclusion: Our results suggest that onion used in the present study has potential for the treatment of UC.