The Prevalence and Molecular Landscape of Lynch Syndrome in the Affected and General Population

The most common genes affected in the diagnostic and EstBB cohorts were <i>MLH1</i> and <i>PMS2</i> genes, respectively. The LS diagnosis mean age was 44.8 years for index cases and 36.8 years (<i>p</i> = 0.003) for family members. In the MMR IHC pilot study, 29% had LS.