Thermal degradation of Affinisol HPMC: Optimum Processing Temperatures for Hot Melt Extrusion and 3D Printing

202322 citationsJournal Articlehybrid Open Access

Authors

Roman Svoboda · University of Pardubice

Marie Nevyhoštěná · University of Pardubice

Jana Macháčková · University of Pardubice

Jan Vaculík · University of Pardubice

Kateřina Knotková · University of Pardubice

Mária Chromčíková · Trencianska Univerzita Alexandra Dubceka V Trencine

Alena Komersová

Abstract

For extrusion temperatures ≥170°C, Affinisol exhibits a significant degree of degradation within the 5 min extruder retention time. Hot melt extrusion of pure Affinisol can be comfortably performed below this temperature. Utilization of plasticizers may be necessary for safe 3D printing.

Topics & Keywords

Thermal and Kinetic Analysis Drug Solubulity and Delivery Systems Injection Molding Process and Properties

UN Sustainable Development Goals

Responsible consumption and production

Publication Details

Published in: Pharmaceutical Research

Volume 40, Issue 9, pp. 2253-2268

DOI: 10.1007/s11095-023-03592-z

Field-Weighted Citation Impact: 2.10