Improved barrier function and skin acceptability of a new cosmetic (body lotion) for atopic-prone skin containing octenidine and silver citrate as antimicrobial agents

Introduction: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, and affects both children and adults. The pathophysiology of atopic dermatitis is complex and involves disruption of skin barrier function, immune dysregulation, genetic susceptibility and interaction with environmental factors. Emollients are considered to be the essential basic component of any treatment, as they are effective in preventing flare-ups and in reducing the symptoms of AD. Objective: To evaluate the skin acceptability and the effect of a new body lotion for atopic skin containing octenidine dihydrochloride and silver citrate upon skin barrier function and. Methods: In-use test under dermatological and pediatric control, applied under normal conditions of use. Nineteen adults between 22-70 years of age (95% women) and 20 children between 7 months and 16 years of age (45% girls) applied the investigational product during four weeks. The frequency of adverse events was recorded and cosmetic acceptability and satisfaction were assessed by means of a survey in both groups, Additionally, transepidermal water loss (TEWL) was measured in the adult group. Results: A significant decrease in TEWL versus baseline was observed after four weeks of repeated applications (10.96 ± 0.99 vs. 7.87 ± 0.41, respectively; p <0.001). There were no side effects or discomfort secondary to application of the emollient, such as irritation or discomfort, as recorded by the investigating dermatologist. The participants had a favorable opinion, particularly regarding the texture, applicability and efficacy of the product. Among the regular users of this type of product, 100% felt it to be “as good as” or “better” than the generally used product. Conclusion: The results obtained confirm the good skin acceptability of the new emollient containing octenidine and silver citrate and suggest that may help improve skin barrier function and contribute to the relief and control of atopic dermatitis.