Eicosanoid-Regulated Myeloid ENaC and Isolevuglandin Formation in Human Salt-Sensitive Hypertension

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Authors

Lale A. Ertuğlu · Vanderbilt University Medical Center

Ashley Pitzer Mutchler · Vanderbilt University Medical Center

Sydney Jamison · Meharry Medical College

Cheryl L. Laffer · Vanderbilt University Medical Center

Fernando Elijovich · Vanderbilt University Medical Center

Mohammad Saleem · Vanderbilt University Medical Center

Daniel J. Blackwell

Abstract

Isolevuglandin formation in APCs responds to acute changes in salt intake in salt-sensitive but not salt-resistant people with hypertension, and this may be regulated by renal 14,15 EET. Baseline levels of isolevuglandin<sup>+</sup> APCs or urinary 14,15 EET may provide diagnostic tools for salt sensitivity without a protocol of salt loading.

Topics & Keywords

Eicosanoids and Hypertension Pharmacology Hormonal Regulation and Hypertension Adipose Tissue and Metabolism

Publication Details

Published in: Hypertension

Volume 81, Issue 3, pp. 516-529

DOI: 10.1161/hypertensionaha.123.21285

Field-Weighted Citation Impact: 4.04

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Eicosanoid-Regulated Myeloid ENaC and Isolevuglandin Formation in Human Salt-Sensitive Hypertension

Authors

Abstract

Topics & Keywords

Publication Details