Targeted DNA Methylation Analysis Facilitates Leukocyte Counts in Dried Blood Samples

202311 citationsJournal Articlebronze Open Access

Authors

Wouter Hubens · RWTH Aachen University

Tiago Maié · RWTH Aachen University

Matthis Schnitker · RWTH Aachen University

Ledio Bocova · RWTH Aachen University

Deepika Puri · RWTH Aachen University

Martina Wessiepe · RWTH Aachen University

Jan Kramer ·

Abstract

The advanced selection of cell-type specific CpGs and utilization of digital droplet PCR analysis provided accurate epigenetic blood counts. Analysis of dried blood facilitates self-sampling with a finger prick, thereby enabling easier accessibility to testing.

Topics & Keywords

Epigenetics and DNA Methylation Immune responses and vaccinations HIV Research and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 69, Issue 11, pp. 1283-1294

DOI: 10.1093/clinchem/hvad143

Field-Weighted Citation Impact: 1.69