Comments on “Relationship between body composition and PBRM1 mutations in clear cell renal cell carcinoma: a propensity score matching analysis”

Kidney cancer is one of the leading causes of cancer-related death worldwide and mainly comprises renal cell carcinoma, with an estimated 0.4 million new cases worldwide in 2018 1 .In 2020, Hu et al. 2 carried out a meta-analysis to evaluate the prognostic value of sarcopenia in patients with renal cell carcinoma and observed that patients with sarcopenia had worse overall survival compared with those without sarcopenia in renal cell carcinoma.They 2 concluded that larger, preferably prospective, studies were needed to confirm and update their findings.Recently, in 2023, Demirel and Dilek 3 published, a study entitled "Relationship between body composition and PBRM1 mutations in clear cell renal cell carcinoma: a propensity score matching analysis" in the Journal of the Brazilian Medical Association 3 , in which they retrospectively examined the relationship between body muscle and adipose tissue composition in clear cell renal cell carcinoma patients with polybromo-1 protein (PBRM1) 4 gene mutation 3 .The study 3 concluded that normal attenuation muscle area is greater in patients with PBMR1 mutation, even after propensity score matching 3 .According to the authors, body composition plays a critical role in understanding the complex effect of PBRM1 3 .This article 3 has the potential to generate new systematic reviews 2 with retrospective designs 3 .As such, to contribute to the authors and journal, we outline a suggestion for novel studies,