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Technology’s fast growth has profoundly impacted myriad areas, including healthcare. Implementing 5G networks offering high-speed and low-latency communication capabilities is one of the most promising technical developments. Parallel to this, artificial intelligence (AI) has become a robust data analysis and decision-making tool. This paper examines how 5G and AI are combined in the context of intelligent healthcare systems. T5G green communication systems must overcome several challenges to satisfy the need for more user capacity, faster network speeds, cheaper pricing, and less resource use. By applying 5G standards, data rates, and device dependability for Industry 4.0 applications may be significantly increased. Advanced security and decreased unauthenticated assaults from various platforms are also covered in the paper. An outline of prospective new technologies and security improvements was provided to safeguard 5G-based intelligent healthcare networks. This paper identifies several research issues and potential future directions for secure 5G-based smart healthcare. This article discusses Industry 4.0, 5G standards, and new research in future wireless communications to explore current research concerns related to 5G technology. A brand-new architecture is also suggested in the paper for Industry 4.0 and 5G-enabled intelligent healthcare systems.