Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression

202365 citationsJournal Articlehybrid Open Access

Authors

Lijie Zhou · First Affiliated Hospital of Zhengzhou University

Yongbo Luo · First Affiliated Hospital of Zhengzhou University

Yuenan Liu · Wuhan Union Hospital

Youmiao Zeng · First Affiliated Hospital of Zhengzhou University

Junwei Tong · Wuhan No.1 Hospital

Mengting Li · Key Laboratory of Guangdong Province

Yaxin Hou

Abstract

MLYCD deficiency facilitates fatty acid synthesis and lipid droplet accumulation to drive progression of renal cell carcinoma, indicating inducing MYLCD as a potential approach to reprogram fatty acid metabolism in kidney cancer.

Topics & Keywords

Cancer, Lipids, and Metabolism Ferroptosis and cancer prognosis Cancer, Hypoxia, and Metabolism

Publication Details

Published in: Cancer Research

Volume 83, Issue 23, pp. 3920-3939

DOI: 10.1158/0008-5472.can-23-0969

Field-Weighted Citation Impact: 16.99

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Fatty Acid Oxidation Mediated by Malonyl-CoA Decarboxylase Represses Renal Cell Carcinoma Progression

Authors

Abstract

Topics & Keywords

Publication Details