The application of HER2 and CD47 CAR-macrophage in ovarian cancer

202376 citationsJournal Articlegold Open Access

Authors

Yizhao Chen · Anhui Medical University

Xiangling Zhu · Anhui Medical University

Hanze Liu · Anhui Medical University

Cunzhi Wang · Anhui Medical University

Yu Chen · Anhui Medical University

Huihui Wang · Anhui Medical University

Yilong Fang ·

Abstract

We demonstrated the inhibition effect of our constructed novel HER2 CAR-M and CD47 CAR-M on target antigen-positive ovarian cancer in vitro and in vivo, and preliminarily verified that this inhibitory effect is due to phagocytosis, promotion of adaptive immunity and effect on tumor microenvironment.

Topics & Keywords

CAR-T cell therapy research Phagocytosis and Immune Regulation Immune Cell Function and Interaction

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Translational Medicine

Volume 21, Issue 1, pp. 654-654

DOI: 10.1186/s12967-023-04479-8

Field-Weighted Citation Impact: 17.66