Expansion of highly interferon-responsive T cells in early-onset Alzheimer’s disease

20231 citationsPreprintgreen Open Access

Authors

Daniel W. Sirkis · University of California, San Francisco

Caroline Warly Solsberg · National Institutes of Health

Taylor P. Johnson · University of California, San Francisco

Luke W. Bonham · University of California, San Francisco

Alexis P. Oddi · University of California, San Francisco

Ethan G. Geier · University of California, San Francisco

Bruce L. Miller

Abstract

ISAG<sup>hi</sup> T cells, apparently primed for antiviral activity, are expanded in EOAD. Additional research into these cells and the role of heightened peripheral IFN signaling in neurodegeneration is warranted.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Single-cell and spatial transcriptomics Alzheimer's disease research and treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.1101/2023.09.26.559634