Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos

202360 citationsJournal Articlegold Open Access

Authors

Rajiv C. McCoy · Johns Hopkins University

Michael C. Summers · University of Kent

Abeo McCollin · University of Kent

Christian S. Ottolini · London Women's Clinic

Kamal Ahuja · London Women's Clinic

Alan H. Handyside · University of Kent

Abstract

We conclude that the combination of meiotic and mitotic aneuploidies drives arrest of human embryos in vitro, as development increasingly relies on embryonic gene expression at the blastocyst stage.

Topics & Keywords

Prenatal Screening and Diagnostics Genetic Syndromes and Imprinting Genomic variations and chromosomal abnormalities

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome Medicine

Volume 15, Issue 1, pp. 77-77

DOI: 10.1186/s13073-023-01231-1

Field-Weighted Citation Impact: 34.84