The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma

202334 citationsJournal Articlehybrid Open Access

Authors

R. Taylor Durall · Brigham and Women's Hospital

Julianna Huang · Brigham and Women's Hospital

Luke Wojenski · Technical Database Services (United States)

Yeying Huang · Brigham and Women's Hospital

Prafulla C. Gokhale · Dana-Farber Cancer Institute

Brittaney A. Leeper · Dana-Farber Cancer Institute

Joshua O. Nash

Abstract

The development of an immunocompetent model of NUT carcinoma that closely mimics the human disease provides a valuable global resource for mechanistic and preclinical studies to improve treatment of this incurable disease.

Topics & Keywords

Protein Degradation and Inhibitors Multiple Myeloma Research and Treatments Ubiquitin and proteasome pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Research

Volume 83, Issue 23, pp. 3846-3860

DOI: 10.1158/0008-5472.can-23-2545

Field-Weighted Citation Impact: 5.23