Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses

202318 citationsReviewgold Open Access

Authors

Ioannis Hannadjas · Queen Mary University of London

Arthur James · Queen Mary University of London

Ross Davenport · Queen Mary University of London

Charlotte Lindsay · Queen Mary University of London

Karim Brohi · Queen Mary University of London

Elaine Cole · Queen Mary University of London

Abstract

Among published studies of TIC, PCCs did not significantly reduce mortality, nor did they increase the risk of VTE. However, the potential thrombotic risk remains a concern that should be addressed in future studies. Several RCTs are currently ongoing to further explore the efficacy and safety of PCC.

Topics & Keywords

Trauma, Hemostasis, Coagulopathy, Resuscitation Trauma and Emergency Care Studies Traumatic Brain Injury and Neurovascular Disturbances

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Critical Care

Volume 27, Issue 1, pp. 422-422

DOI: 10.1186/s13054-023-04688-z

Field-Weighted Citation Impact: 3.90